張培均 | Pei-Chun Chang
Status Full Time Faculty
Name 張培均 | Pei-Chun Chang
Email peichun.chang@gmail.com
Job title Associate Professor
Education PhD in Chemistry, National Taiwan University, Taiwan
Expertise Chemistry
Research Areas Biomedical Informatics, Computational Chemistry
Office  I416
Phone +886-423323456 ext.1868
Websites Office HourWebpageTeacher Eportfolio
Year Paper Title
2022 Yen-Chang Chen、張培均(Pei-Chun Chang)、葉威蘭(Wei-Lan Yeh)*, Cardamonin attenuates phorbol 12-myristate 13-acetate-induced pulmonary inflammation in alveolar macrophages, FOOD AND CHEMICAL TOXICOLOGY
2021 Yen-Chang Chen、張培均(Pei-Chun Chang)、葉威蘭(Wei-Lan Yeh)*, Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation, Frontiers in Pharmacology
2018 Yali Xiao、張培均(Pei-Chun Chang)*, The potential inhibitors in traditional Chinese medicine for Bcr-Abl T315I mutation of chronic myelogenous leukemia, Medicinal Chemistry
2018 Tsai CF、Chang PC、Yeh WL(Yeh WL)*, Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines, FOOD AND CHEMICAL TOXICOLOGY
2017 Huang BR、Chang PC、Lu DY(Lu DY)*, EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture., Scientific Reports
2017 Tsai CF、Chang PC、Yeh WL(Yeh WL)*, Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers., TOXICOLOGY AND APPLIED PHARMACOLOGY
2016 Lin HY、Chang PC、Lu DY(Lu DY)*, Cobalt protoporphyrin upregulates cyclooxygenase-2 expression through a heme oxygenase-independent mechanism., MOLECULAR NEUROBIOLOGY
2016 Tang HC、Chang PC、Chen YC(Chen YC)*, Iron depletion strategy for targeted cancer therapy: utilizing the dual roles of neutrophil gelatinase-associated lipocalin protein., JOURNAL OF MOLECULAR MODELING
2016 Chen KB、Chang PC、Chen YC(Chen YC)*, In silico investigation of traditional chinese medicine for potential lead compounds as spg7 inhibitors against coronary artery disease., MACROMOLECULES
2016 Chang YL、Chang PC、Chen YC(Chen YC)*, Investigation of the inhibitors of histone-lysine N-methyltransferase SETD2 for acute lymphoblastic leukaemia from traditional Chinese medicine., SAR AND QSAR IN ENVIRONMENTAL RESEARCH
2016 Chen JH、Chang PC、Lu DY(Lu DY)*, Interlukin-18 is a pivot regulatory factor on matrix metalloproteinase-13 expression and brain astrocytic migration., CELLULAR AND MOLECULAR NEUROBIOLOGY
2015 Ling-Hsuan Wu、Chingju Lin、Hsiao-Yun Lin、Yu-Shu Liu、蔡政芳(Cheng-Fang Tsai)、張培均(Pei-Chun Chang)、Wei-Lan Yeh、Dah-Yuu Lu, Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression, MOLECULAR NEUROBIOLOGY
2014 蕭雅莉(Ya-Li Hsiao)、張培均(Pei-Chun Chang)、Hung-Jin Huang, Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine, Evidence-based Complementary and Alternative Medicine
2014 Huang BR、張培均(Pei-Chun Chang)、Yeh WL、Lee CH、蔡政芳(Cheng-Fang Tsai)、Lin C、Lin HY、Liu YS、Wu CY,、Ko PY、Huang SS、Hsu HC、Lu DY., Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications forneuroprotection., PLoS One, vol.9 no.3 pp.e91167-
2014 Wang CC、張培均(Pei-Chun Chang)、吳家樂(Ng, Ka-Lok)、張春明(Chun-Ming Chang)、許承瑜(Sheu, Phillip C.Y.)、蔡進發(JEFFREY J. P. TSAI), A model comparison study of the flowering time regulatory network in Arabidopsis, BMC Systems Biology, vol.11 no.8 pp.15-
2014 Chuang JY、張培均(Pei-Chun Chang)、Shen YC、Lin C、蔡政芳(Cheng-Fang Tsai)、Chen JH、Yeh WL、、、、, Regulatory effects of fisetin on microglial activation., MOLECULES, vol.19 no.7 pp.8820-
2013 Hung, I-Chi、Chang, Su-Sen、張培均(Pei-Chun Chang)、Cheng-Chun Lee、Chen, Calvin Yu-Chian, Memory-Enhancement by Traditional Chinese Medicine?, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol.31 no.12 pp.1411-1439
2011 張培均(Pei-Chun Chang)、Yi Chen、Ming-Tsong Lai、Heng-Yuan Chang、Chung-Ming Huang、Wei-Yong Lin、Chin-Ho Lai、Jim Jinn-Chyuan Sheu、Fuu-Jen Tsai, Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in taiwan chinese han population., Turkish Journal of Rheumatology, vol.38 pp.2376-2381
2011 張培均(Pei-Chun Chang)、王經篤(Jing-Doo Wang)、李明明(Min-Min Lee)、Su-Sen Chang、Tsung-Ying Tsai、Kai-Wei Chang、Fuu-Jen Tsai、Yu-Chian Chen, Lose weight with traditional chinese medicine? potential suppression of fat mass and obesity-associated protein., JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol.29 pp.424-596
2008 蕭震緯(Chen-Wei Hsiao)、張培均(Pei-Chun Chang)、蔡進發(Jeffrey J. P. Tsai), Predicting subcellular locations of eukaryotic proteins using bayesian and k-nearest neighbor classifiers, JOURNAL OF INFORMATION SCIENCE AND ENGINEERING, vol.24 pp.1361-1375
2007 張培均(Pei-Chun Chang)*, Genome-wide identification of specific oligonucleotides using artificial neural network and computational genomic analysis, BMC BIOINFORMATICS, vol.8 pp.164-
2006 張培均(Pei-Chun Chang)*, CRSD: a comprehensive web server for composite regulatory signature discovery., NUCLEIC ACIDS RESEARCH, vol.34 pp.W571-W577
2006 張培均(Pei-Chun Chang)*, Topology-based cancer classification and related pathway mining using microarray data, NUCLEIC ACIDS RESEARCH
2005 張培均(Pei-Chun Chang)*, 拓樸人工基因網路在癌症分類上的發展與應用, 台灣醫學, vol.9 no.5 pp.650-666
2003 張培均(Pei-Chun Chang), Design and assessment of a fast algorithm for identifying specific probes for human and mouse genes, BIOINFORMATICS, vol.19 no.11 pp.1311-1317
Year Book Title
2017 Computational Methods with Applications in Bioinformatics Analysis, World Scientific Publishing, 2017/08
Date of Publication Paper Title
2018.10 Jhih-Ying Chen、張培均(Pei-Chun Chang), Proceedings of the 18th IEEE International Conference on BioInformatics and BioEngineering, 台灣
2018.01 Jhih-Ying Chen、張培均(Pei-Chun Chang), The 8th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2018), 日本
2017.05 Yali Xiao、張培均(Pei-Chun Chang), The 21st Annual International Conference on Research in Computational Molecular Biology (RECOMB2017), 香港
2016.10 Yali Xiao、張培均(Pei-Chun Chang), The 6th Annual Translational Bioinformatics Conference (TBC2016), 韓國
2014.01 Jia-Zhen Guo、張培均(Pei-Chun Chang), Asia Pacific Bioinformatics Conference (APBC2014), 中國
2011.01 Theoretical Assessment of Immunogenicity Variation on The HA protein of H2N2 influenza virus by using fuzzy integral and SVM classifier. , Proceedings of 2011 International Conference on Machine Learning and Cybernetics., 中國
2011.01 Choquet integral algorithm for T, cell epitope prediction based on fuzzy measure. - The 8th International Conference on Fuzzy Systems and Knowledge Discovery., 中國
2010.01 Coupling Effects of Amino Acids in T, cell Epitope Prediction - 4th Asian Young Researchers Conference on Computation and Omics Biology, 新加坡
2010.01 Choquet integral algorithm for thermostable proteins based on Hurst exponent and generalized L, measure. - Proceedings of the ninth International Conference on Machine Learning and Cybernetics., 中國
2009.01 A novel predicting algorithm of thermostable proteins based on choquet integral with respect to l, measure and hurst exponent. - International Conference on Machine Learning and Cybernetics, 中國
2009.01 Detection of epilepsy events in the EEG by mimetic signatures and nonlinear dynamic indications. , International Conference on Bioinformatics (InCoB), 新加坡
2009.01 Nonlinear dynamic indications in time Series of epilepsy electroencephalogram. , The Ninth IEEE International Conference on Bioinformatics and Bioengineering., 台灣
2008.01 A novel classifier for influenz A viruses based on svm and logistic regression. , The International Conference on Wavelet Analysis and Pattern Recognition (ICWAPR) 2008., 香港
2008.01 Physiochemical constraints in influenza A hemagglutinin. , The 4rd International Conference on Natural Computation (ICNC'08)., 中國
2005.01 Topological, based classification using artificial gene networks. - The 4th IEEE International Conference on Cognitive Informatics., 美國
2004.01 Prediction of specific probes with neural network model. , The 21st Workshop on Combinatorial Mathematics and Computational Theory., 台灣
Project Title Participator Period
抗阿茲海默症藥物探勘-應用AI技術預測P2Y1蛋白的抑制化合物 (111-2813-C-468-029-E) 張培均(Pei-Chun Chang) 2022.07 ~ 2023.02
ACE2變異蛋白的抑制化合物探勘 (111-2813-C-468-031-E) 張培均(Pei-Chun Chang) 2022.07 ~ 2023.02
科普活動:南投縣全民科學活動計畫(主題四) (MOST 110-2515-S-468-001) 張培均(Pei-Chun Chang)、鄧金培(JP Deng) 2021.08 ~ 2022.12
應用AI技術探勘CTSL蛋白的抑制化合物 (110-2813-C-468-027-E) 張培均(Pei-Chun Chang) 2021.07 ~ 2022.02
抑制血管收縮素轉化?(ACE2)的中草藥成份探勘 (109-2813-C-468-029-E) 張培均(Pei-Chun Chang) 2020.07 ~ 2021.02
基於模糊積分演算法來預測流感病毒HA蛋白質的抗原決定位 (20121107150122) 張培均(Pei-Chun Chang) 2011.12 ~ 2011.11
從微陣列資料探勘癌症相關基因網路 (99-2221-E-468-010-) 張培均(Pei-Chun Chang) 2010.08 ~ 2011.07
流感A型病毒HA蛋白的演化與變異 (98-2221-E-468-021-) 張培均(Pei-Chun Chang) 2009.08 ~ 2010.07
以生物合成方式產生不同分子量玻尿酸 (20121107145340) 張培均(Pei-Chun Chang) 2008.12 ~ 2009.11
癌症細胞生化路徑網路的交互作用 (96-2221-E-468-012-MY2) 張培均(Pei-Chun Chang) 2007.08 ~ 2009.07
利用資料探勘建立中醫藥系統生物學網路(I) (20121107145929) 張培均(Pei-Chun Chang)
Biofunctional networking of Chinese herb WuChuYu in cancer cells (20121107145622) 張培均(Pei-Chun Chang)
整合型計算醫學應用於動脈粥狀硬化疾病(102-2632-E-468-001-MY3)
從中草藥成份中探勘抗急性淋巴細胞性血癌之多標靶抑制化合物(104-2221-E-468-015-)
以生醫大數據分析為基礎的精準癌症醫療研究(1/3)(105-2632-E-468-002-)
誘發血管栓塞之合成致病基因探勘(105-2221-E-468-020-)
以生醫大數據分析為基礎的精準癌症醫療研究(2/3)(106-2632-E-468-002-)
以生醫大數據分析為基礎的精準癌症醫療研究(3/3)(106-2632-E-468-002-)
Category Course Code Course Title Year
Bachelor's programs TK300099A 長期照護之統計分析概論 111
Bachelor's programs GRG00260A 資訊科技概論 111
Bachelor's programs GRG00093S 資訊與科技 111
Bachelor's programs GRG00093AM 資訊與科技 111
Bachelor's programs EB300470A 系統生物學 111
Bachelor's programs EB300145A 普通化學 111