張培均 | Pei-Chun Chang
Status Full Time Faculty
Name 張培均 | Pei-Chun Chang
Email
Job title Associate Professor
Education PhD in Chemistry, National Taiwan University, Taiwan
Expertise Chemistry
Research Areas Biomedical Informatics, Computational Chemistry
Office  I416
Phone +886-423323456 ext.1868
Websites Office Hour、Webpage、Teacher Eportfolio
Year Paper Title
2022 Yen-Chang Chen、Chen-Teng Wu、Jia-Hong Chen、蔡政芳(Cheng-Fang Tsai)、Chen-Yun Wu、張培均(Pei-Chun Chang)、Wei-Lan Yeh(Wei-Lan Yeh)*, Diltiazem inhibits breast cancer metastasis via mediating growth differentiation factor 15 and epithelial-mesenchymal transition, Oncogenesis, 2022
2022 Yen-Chang Chen、張培均(Pei-Chun Chang)、葉威蘭(Wei-Lan Yeh)*, Cardamonin attenuates phorbol 12-myristate 13-acetate-induced pulmonary inflammation in alveolar macrophages, FOOD AND CHEMICAL TOXICOLOGY, 2022
2021 Yen-Chang Chen、張培均(Pei-Chun Chang)、葉威蘭(Wei-Lan Yeh)*, Nicardipine Inhibits Breast Cancer Migration via Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation, Frontiers in Pharmacology, 2021
2018 Tsai CF、Chang PC、Yeh WL(Yeh WL)*, Fisetin inhibits cell migration via inducing HO-1 and reducing MMPs expression in breast cancer cell lines, FOOD AND CHEMICAL TOXICOLOGY, 2018
2018 Yali Xiao、張培均(Pei-Chun Chang)*, The potential inhibitors in traditional Chinese medicine for Bcr-Abl T315I mutation of chronic myelogenous leukemia, Medicinal Chemistry, 2018
2017 Tsai CF、Chang PC、Yeh WL(Yeh WL)*, Inhibition of estrogen receptor reduces connexin 43 expression in breast cancers., TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017
2017 Huang BR、Chang PC、Lu DY(Lu DY)*, EGFR is a pivotal regulator of thrombin-mediated inflammation in primary human nucleus pulposus culture., Scientific Reports, 2017
2016 Chen JH、Chang PC、Lu DY(Lu DY)*, Interlukin-18 is a pivot regulatory factor on matrix metalloproteinase-13 expression and brain astrocytic migration., CELLULAR AND MOLECULAR NEUROBIOLOGY, 2016
2016 Chang YL、Chang PC、Chen YC(Chen YC)*, Investigation of the inhibitors of histone-lysine N-methyltransferase SETD2 for acute lymphoblastic leukaemia from traditional Chinese medicine., SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2016
2016 Chen KB、Chang PC、Chen YC(Chen YC)*, In silico investigation of traditional chinese medicine for potential lead compounds as spg7 inhibitors against coronary artery disease., MACROMOLECULES, 2016
2016 Tang HC、Chang PC、Chen YC(Chen YC)*, Iron depletion strategy for targeted cancer therapy: utilizing the dual roles of neutrophil gelatinase-associated lipocalin protein., JOURNAL OF MOLECULAR MODELING, 2016
2016 Lin HY、Chang PC、Lu DY(Lu DY)*, Cobalt protoporphyrin upregulates cyclooxygenase-2 expression through a heme oxygenase-independent mechanism., MOLECULAR NEUROBIOLOGY, 2016
2015 Ling-Hsuan Wu、Chingju Lin、Hsiao-Yun Lin、Yu-Shu Liu、蔡政芳(Cheng-Fang Tsai)、張培均(Pei-Chun Chang)、Wei-Lan Yeh、Dah-Yuu Lu, Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression, MOLECULAR NEUROBIOLOGY, 2015
2014 Chuang JY、張培均(Pei-Chun Chang)、Shen YC、Lin C、蔡政芳(Cheng-Fang Tsai)、Chen JH、Yeh WL、、、、, Regulatory effects of fisetin on microglial activation., MOLECULES, vol.19 no.7 pp.8820-, 2014
2014 Wang CC、張培均(Pei-Chun Chang)、吳家樂(Ng, Ka-Lok)、張春明(Chun-Ming Chang)、許承瑜(Sheu, Phillip C.Y.)、蔡進發(JEFFREY J. P. TSAI), A model comparison study of the flowering time regulatory network in Arabidopsis, BMC Systems Biology, vol.11 no.8 pp.15-, 2014
2014 Huang BR、張培均(Pei-Chun Chang)、Yeh WL、Lee CH、蔡政芳(Cheng-Fang Tsai)、Lin C、Lin HY、Liu YS、Wu CY,、Ko PY、Huang SS、Hsu HC、Lu DY., Anti-neuroinflammatory effects of the calcium channel blocker nicardipine on microglial cells: implications forneuroprotection., PLoS One, vol.9 no.3 pp.e91167-, 2014
2014 蕭雅莉(Ya-Li Hsiao)、張培均(Pei-Chun Chang)、Hung-Jin Huang, Treatment of Acute Lymphoblastic Leukemia from Traditional Chinese Medicine, Evidence-based Complementary and Alternative Medicine, 2014
2013 Hung, I-Chi、Chang, Su-Sen、張培均(Pei-Chun Chang)、Cheng-Chun Lee、Chen, Calvin Yu-Chian, Memory-Enhancement by Traditional Chinese Medicine?, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol.31 no.12 pp.1411-1439, 2013
2011 張培均(Pei-Chun Chang)、王經篤(Jing-Doo Wang)、李明明(Min-Min Lee)、Su-Sen Chang、Tsung-Ying Tsai、Kai-Wei Chang、Fuu-Jen Tsai、Yu-Chian Chen, Lose weight with traditional chinese medicine? potential suppression of fat mass and obesity-associated protein., JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol.29 pp.424-596, 2011
2011 張培均(Pei-Chun Chang)、Yi Chen、Ming-Tsong Lai、Heng-Yuan Chang、Chung-Ming Huang、Wei-Yong Lin、Chin-Ho Lai、Jim Jinn-Chyuan Sheu、Fuu-Jen Tsai, Association analysis of polymorphisms in lumican gene and systemic lupus erythematosus in taiwan chinese han population., Turkish Journal of Rheumatology, vol.38 pp.2376-2381, 2011
2008 蕭震緯(Chen-Wei Hsiao)、張培均(Pei-Chun Chang)、蔡進發(Jeffrey J. P. Tsai), Predicting subcellular locations of eukaryotic proteins using bayesian and k-nearest neighbor classifiers, JOURNAL OF INFORMATION SCIENCE AND ENGINEERING, vol.24 pp.1361-1375, 2008
2007 張培均(Pei-Chun Chang)*, Genome-wide identification of specific oligonucleotides using artificial neural network and computational genomic analysis, BMC BIOINFORMATICS, vol.8 pp.164-, 2007
2006 張培均(Pei-Chun Chang)*, Topology-based cancer classification and related pathway mining using microarray data, NUCLEIC ACIDS RESEARCH, 2006
2006 張培均(Pei-Chun Chang)*, CRSD: a comprehensive web server for composite regulatory signature discovery., NUCLEIC ACIDS RESEARCH, vol.34 pp.W571-W577, 2006
2005 張培均(Pei-Chun Chang)*, 拓樸人工基因網路在癌症分類上的發展與應用, 台灣醫學, vol.9 no.5 pp.650-666, 2005
2003 張培均(Pei-Chun Chang), Design and assessment of a fast algorithm for identifying specific probes for human and mouse genes, BIOINFORMATICS, vol.19 no.11 pp.1311-1317, 2003
Year Book Title
2017 Computational Methods with Applications in Bioinformatics Analysis, World Scientific Publishing, Aug. 2017
Date of Publication Paper Title
2018.10 Jhih-Ying Chen、張培均(Pei-Chun Chang), Proceedings of the 18th IEEE International Conference on BioInformatics and BioEngineering, Oct. 2018, 台灣
2018.01 Jhih-Ying Chen、張培均(Pei-Chun Chang), The 8th International Conference on Bioscience, Biochemistry and Bioinformatics (ICBBB 2018), Jan. 2018, 日本
2017.05 Yali Xiao、張培均(Pei-Chun Chang), The 21st Annual International Conference on Research in Computational Molecular Biology (RECOMB2017), May. 2017, 香港
2016.10 Yali Xiao、張培均(Pei-Chun Chang), The 6th Annual Translational Bioinformatics Conference (TBC2016), Oct. 2016, 韓國
2014.01 Jia-Zhen Guo、張培均(Pei-Chun Chang), Asia Pacific Bioinformatics Conference (APBC2014), Jan. 2014, 中國
2011.01 Choquet integral algorithm for T, cell epitope prediction based on fuzzy measure. - The 8th International Conference on Fuzzy Systems and Knowledge Discovery., Jan. 2011, 中國
2011.01 Theoretical Assessment of Immunogenicity Variation on The HA protein of H2N2 influenza virus by using fuzzy integral and SVM classifier. , Proceedings of 2011 International Conference on Machine Learning and Cybernetics., Jan. 2011, 中國
2010.01 Choquet integral algorithm for thermostable proteins based on Hurst exponent and generalized L, measure. - Proceedings of the ninth International Conference on Machine Learning and Cybernetics., Jan. 2010, 中國
2010.01 Coupling Effects of Amino Acids in T, cell Epitope Prediction - 4th Asian Young Researchers Conference on Computation and Omics Biology, Jan. 2010, 新加坡
2009.01 Nonlinear dynamic indications in time Series of epilepsy electroencephalogram. , The Ninth IEEE International Conference on Bioinformatics and Bioengineering., Jan. 2009, 台灣
2009.01 Detection of epilepsy events in the EEG by mimetic signatures and nonlinear dynamic indications. , International Conference on Bioinformatics (InCoB), Jan. 2009, 新加坡
2009.01 A novel predicting algorithm of thermostable proteins based on choquet integral with respect to l, measure and hurst exponent. - International Conference on Machine Learning and Cybernetics, Jan. 2009, 中國
2008.01 Physiochemical constraints in influenza A hemagglutinin. , The 4rd International Conference on Natural Computation (ICNC'08)., Jan. 2008, 中國
2008.01 A novel classifier for influenz A viruses based on svm and logistic regression. , The International Conference on Wavelet Analysis and Pattern Recognition (ICWAPR) 2008., Jan. 2008, 香港
2005.01 Topological, based classification using artificial gene networks. - The 4th IEEE International Conference on Cognitive Informatics., Jan. 2005, 美國
2004.01 Prediction of specific probes with neural network model. , The 21st Workshop on Combinatorial Mathematics and Computational Theory., Jan. 2004, 台灣
Project Title Participator Period
科普活動：南投縣偏鄉科普推廣計畫 (NSTC 113-2515-S-468-001) 張培均(Pei-Chun Chang)、施養佳(Yang-Chia Shih)、陳政煥 2024.08 ~ 2025.07
科普活動：南投縣偏鄉科普推廣計畫(主題四) (NSTC 112-2515-S-468-001-) 張培均(Pei-Chun Chang)、施養佳(Yang-Chia Shih) 2023.08 ~ 2024.07
ACE2變異蛋白的抑制化合物探勘 (111-2813-C-468-031-E) 張培均(Pei-Chun Chang) 2022.07 ~ 2023.02
抗阿茲海默症藥物探勘-應用AI技術預測P2Y1蛋白的抑制化合物 (111-2813-C-468-029-E) 張培均(Pei-Chun Chang) 2022.07 ~ 2023.02
科普活動：南投縣全民科學活動計畫(主題四) (MOST 110-2515-S-468-001) 張培均(Pei-Chun Chang)、鄧金培(JP Deng) 2021.08 ~ 2022.12
應用AI技術探勘CTSL蛋白的抑制化合物 (110-2813-C-468-027-E) 張培均(Pei-Chun Chang) 2021.07 ~ 2022.02
抑制血管收縮素轉化?(ACE2)的中草藥成份探勘 (109-2813-C-468-029-E) 張培均(Pei-Chun Chang) 2020.07 ~ 2021.02
基於模糊積分演算法來預測流感病毒HA蛋白質的抗原決定位 (20121107150122) 張培均(Pei-Chun Chang) 2011.12 ~ 2011.11
從微陣列資料探勘癌症相關基因網路 (99-2221-E-468-010-) 張培均(Pei-Chun Chang) 2010.08 ~ 2011.07
流感A型病毒HA蛋白的演化與變異 (98-2221-E-468-021-) 張培均(Pei-Chun Chang) 2009.08 ~ 2010.07
以生物合成方式產生不同分子量玻尿酸 (20121107145340) 張培均(Pei-Chun Chang) 2008.12 ~ 2009.11
癌症細胞生化路徑網路的交互作用 (96-2221-E-468-012-MY2) 張培均(Pei-Chun Chang) 2007.08 ~ 2009.07
以生醫大數據分析為基礎的精準癌症醫療研究(3/3)(106-2632-E-468-002-)
以生醫大數據分析為基礎的精準癌症醫療研究(2/3)(106-2632-E-468-002-)
誘發血管栓塞之合成致病基因探勘(105-2221-E-468-020-)
以生醫大數據分析為基礎的精準癌症醫療研究(1/3)(105-2632-E-468-002-)
從中草藥成份中探勘抗急性淋巴細胞性血癌之多標靶抑制化合物(104-2221-E-468-015-)
整合型計算醫學應用於動脈粥狀硬化疾病(102-2632-E-468-001-MY3)
Biofunctional networking of Chinese herb WuChuYu in cancer cells (20121107145622) 張培均(Pei-Chun Chang)
利用資料探勘建立中醫藥系統生物學網路(I) (20121107145929) 張培均(Pei-Chun Chang)
Category Course Code Course Title Year
Bachelor's programs EB300089A 生物統計學 113
Bachelor's programs EB300089B 生物統計學 113
Bachelor's programs EB301031A 體學導論(基因體、蛋白質體) 113
Year Project name Advising professor Student name
111 ACE2變異蛋白的抑制化 合物探勘 張培均 劉芳語
111 抗阿茲海默症藥物探勘- 應用AI技術預測P2Y1蛋 白的抑制化合物 張培均 張宜丹
110 應用AI技術探勘CTSL蛋白的抑制化合物 張培均 馮馨
109 抑制血管收縮素轉化?(ACE2)的中草藥成份探勘 張培均 陳家妤
Activity Name Organizer Area Start Date End Date
南投縣虛實整合科普元宇宙 南投縣草屯國小 2023-05-22 2023-05-22